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Thiamine (Vitamin B1)

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  • Thiamine (vitamin B1) is a water-soluble vitamin that is crucial for normal carbohydrate metabolism. Lack of dietary thiamine can create serious health problems for your pet; cats are at much higher risk of thiamine deficiency than dogs.
  • Canned pet food is most often associated with inadequate amounts of thiamine, but dry foods, and unbalanced raw and homemade diets can also be deficient. Other contributors can include high-carbohydrate diets that demand excessive amounts of thiamine for processing, intestinal disease that causes malabsorption of nutrients, certain medications, a diet containing too much raw fish, and pet foods containing sulfites.
  • Symptoms of thiamine deficiency in pets typically start with GI disturbances like vomiting, excessive drooling, and lack of appetite, and left untreated, can progress within weeks to neurological signs and ultimately, death.
  • Diagnosis is most often accomplished through a review of the pet’s symptoms and dietary history, and response to treatment, which should be initiated immediately if a thiamine deficiency is suspected.
  • Treatment involves instituting a balanced, species-appropriate diet that does not include raw fish. It is also often advisable to provide thiamine injections for a few days, followed by oral supplementation for two to four weeks. Certain pets may benefit from ongoing vitamin B1 supplementation.
 

This Feeding Mistake Can Lead to a Fatal Deficiency

April 30, 2014 | 43,636 views
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By Dr. Becker

Thiamine, or vitamin B1, is a water-soluble vitamin absorbed from the diet through the small intestine, and is necessary for normal carbohydrate metabolism. Organs that use a lot of energy, like the brain, can be severely compromised by a thiamine deficiency. A lack of thiamine can also lead to a buildup of lactate, resulting in acidosis.

How Your Pet Can Become Thiamine-Deficient

In recent years, there have been several major recalls in the U.S. for thiamine-deficient pet foods. Cats require about three times the amount of dietary thiamine that dogs do, which puts kitties at significantly higher risk for developing a deficiency.

Canned diets are the type most commonly deficient in thiamine because of the way they are processed, but dry foods exposed to air, humidity or heat can also lose thiamine content. An unbalanced raw or homemade diet can also be thiamine-deficient.

Pets fed high-carbohydrate foods may experience deficiencies because their bodies have a greater demand for thiamine to metabolize all those carbs. In addition, animals with intestinal disease that interferes with nutrient absorption may be thiamine-deficient, as well as pets taking certain medications like diuretics.

A thiamine deficiency can also develop from feeding pets large amounts of raw fish containing the enzyme thiaminase, which destroys thiamine, and also from feeding pet food containing sulfites, which inactivate thiamine.

Symptoms of Thiamine Deficiency

Progressive symptoms of a thiamine deficiency can take weeks to develop, but initial signs of general GI upset including vomiting, excessive salivation, loss of appetite, and weight loss, often occur within a week after an animal begins eating a diet severely lacking in thiamine.

If the deficiency remains untreated, neurological signs will follow. These can include:

  • Dilated pupils
  • Loss of coordination
  • Head tilt
  • Circling
  • Abnormal gait
  • Ventriflexion (bending downward) or curling of the neck backward
  • Arching of the head, neck, and spine
  • Falling
  • Stupor
  • Seizures

Typically, a pet must be thiamine deficient for around a month before the terminal stage is reached. Once an animal has entered this stage, he or she will die within a few days if the deficiency is not immediately reversed.

Diagnosis and Treatment

Diagnosing thiamine deficiency in a dog or cat can be somewhat complicated. Thiamine exists in several forms in an animal's body, and measuring the concentrations can be a challenge.

Two tests are typically used to evaluate a pet's thiamine status – one is the erythrocyte transketolase activity assay, and the other is high-pressure liquid chromatography. Most often, however, thiamine deficiency is diagnosed based on the animal's symptoms, dietary history, and response to treatment. (When the cause of a pet's illness is suspected to be thiamine deficiency, it's important to initiate treatment immediately, even without a confirmed diagnosis.)

Treatment of a thiamine deficiency involves feeding a balanced, species-appropriate diet, and limiting or eliminating raw fish. If you want to feed your pet fish occasionally, I recommend sardines packed in water.

Often thiamine is given by injection for three to five days, followed by oral supplementation for two to four weeks.

Since natural food sources of thiamine aren't, for the most part, species-appropriate food for felines, if your pet is a cat, I also recommend talking to your holistic vet about supplementing thiamine depending on what diet you feed. If you're feeding a variety of high-quality, human grade commercial cat foods, you may not need to add more thiamine. If you're feeding a lesser quality brand or are preparing your pet's meals at home, a vitamin B1 supplement may be advisable.



[+] Sources and References

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